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. 2020 Oct 14;11:567348. doi: 10.3389/fimmu.2020.567348

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Copyright © 2020 Kennedy, Haralambieva, Ovsyannikova, Voigt, Larrabee, Schaid, Zimmermann, Oberg and Poland

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WT and H232 STING-mediated IFN response in stably transduced BJAB cells. (A) Time course of IFNA, IFNB, IFNL1 gene expression after cGAMP stimulation. (B) Time course of cytokine secretion after cGAMP stimulation. (C) Activation of representative interferon-stimulated genes after cGAMP stimulation. All data points in (A, C) are means and error bars representing the standard deviations of total of eight replicates coming from four biological duplicates. For cytokine secretion (B) biological duplicate samples from each timepoint were each assayed in duplicate for a total of four replicates. Each experiment was performed twice. Two-tailed t-test: *p < 0.05. **p < 0.005.