Table 1.

Top SNPs significantly associated with vaccinia virus-specific IFNα secretion.

SNP	ChromosomeLocation	Gene	SNPFunction	GeneLocation	p-value	Minorallele	Majorallele	MAF
rs7447927	138861146	TMEM173	protein-coding	synonymous	1.49E-36	C	G	34.7%
rs13166214	138862744	TMEM173	protein-coding	5’upstream	8.92E-36	A	G	35.3%
rs7444313	138865423	TMEM173	protein-coding	5’upstream	1.41E-35	G	A	34.5%
rs13181561	138850905	TMEM173	protein-coding	3’downstream	1.81E-34	G	A	30.0%
rs55792153	138854203	TMEM173	protein-coding	3’downstream	1.26E-32	A	C	34.2%
rs13153461	138852369	TMEM173	protein-coding	3’downstream	2.61E-32	G	A	31.4%
rs9716069	138842818	ECSCR	protein-coding	5’upstream	5.32E-31	T	A	31.3%
rs28419191	138844599	ECSCR	protein-coding	5’upstream	1.50E-22	T	C	13.2%
rs1131769	138857919	TMEM173	protein-coding	missense	5.25E-22	T	C	14.0%
rs11954057	138783832	RNU5B-4P	pseudo	3’downstream	8.99E-22	C	G	32.5%
rs36137978	138785565	ECSCR	protein-coding	5’upstream	1.13E-21	C	A	31.6%
rs10875554	138847652	ECSCR	protein-coding	5’upstream	1.99E-21	A	C	15.4%
rs6596479	138780599	RNU5B-4P	pseudo	5’upstream	5.63E-21	C	T	31.9%
rs7446197	138783734	RNU5B-4P	pseudo	3’downstream	7.51E-21	A	G	33.8%
rs10463977	138781765	RNU5B-4P	pseudo	5’upstream	1.80E-20	C	T	32.4%
rs2434576	138917674	UBE2D2	protein-coding	5’upstream	6.57E-17	G	A	30.8%
rs34530489	138873627	LOC642262	pseudo	gene	7.00E-17	G	A	31.4%
rs35779874	138869847	LOC642262	pseudo	5’upstream	1.11E-16	A	G	31.2%
rs7378724	138876953	LOC642262	pseudo	gene	1.13E-16	G	A	30.9%
rs78233829	138857925	TMEM173	protein-coding	missense	3.16E-13	G	C	17.6%
rs11554776	138861078	TMEM173	protein-coding	missense	1.05E-12	T	C	16.5%
rs7380824	138856982	TMEM173	protein-coding	missense	1.25E-12	T	C	17.7%

MAF, minor allele frequency. Bold, italics – SNP studied in this report. Bold – SNPs in HAQ STING haplotype.