Table 2.
The Effect of rs1131769 on IFNα Response is Independent of the Effect Mediated by the HAQ Haplotype.
| Term in Model | Regression Coefficient** | Standard Error of Coefficient | p-value*** | Haplotype Frequency |
|---|---|---|---|---|
| Intercept | 0.31 | 0.037 | <2E-16 | |
| Cohort US vs. SD | 0.037 | 0.044 | 0.40 | |
| Haplotypes* | ||||
| CCCC | Baseline | 0.683 | ||
| CCCT (H232) | −0.011 | 0.307 | 0.97 | 0.002 |
| CCTC (Q293) | −0.546 | 0.045 | <2e−16 | 0.139 |
| CGCT (AQ) | −0.281 | 0.146 | 0.05 | 0.011 |
| TGCT (HAQ) | −0.409 | 0.042 | <2e−16 | 0.164 |
*TMEM173 SNPs (haplotype) from left to right: rs11554776 (encodes amino acid/AA change at position 71) —rs78233829 (encodes AA change at position 230) — rs1131769 (encodes AA change at position 232) — rs7380824 (encodes AA change at position 293). In bold are designated the minor alleles defining the respective haplotypes, and in italics are designated the commonly used names of the haplotypes (that are based on encoded amino acid/acids and their position).
**Regression coefficients from regression analysis of TMEM173 SNP haplotypes with IFNα response. Show the direction and magnitude of the estimated haplotypic effect on IFNα response compared to the haplotype (CCCC) with the greatest population frequency.
***P-value from regression analysis.