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. 2020 Oct 14;14:590029. doi: 10.3389/fnins.2020.590029

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Copyright © 2020 Requejo, López-de-Ipiña, Ruiz-Ortega, Fernández, Calvo, Morera-Herreras, Miguelez, Cardona-Grifoll, Cepeda, Ugedo and Lafuente.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morpho-functional correlation between amphetamine-induced rotations and dopaminergic neurons in SN in addition to dopaminergic terminals in both striatum and SN after 6-OHDA administration. (A) Amphetamine-induced IL rotations correlate negatively with the % of TH-ir striatal volume IL, (B) also with the % of TH-ir neuronal density and (C) with the % of TH-ir ADN density. Significance. p < 0.05, IL rotations vs. TH-ir neurons. SN, substantia nigra; 6-OHDA, 6-hydroxydopamine; TH-ir, tyrosine hydroxylase immunoreactivity; IL, ipsilateral.