FIGURE 1.

Enhancement of GABA-induced currents by humulone in recombinant α1β3γ2 GABA_A receptors expressed in HEK293 cells and voltage-clamped at −60 mV, pH 7.4. (A) Chemical structures of humulone and GABA. (B) Representative current traces of receptor activation upon 1 min application of a submaximal concentration of GABA (1 μM) in the presence or absence of humulone (10 μM). (C) Bar graph illustrating the peak current amplitude normalized to that induced by the presence of 1 μM GABA alone. Each vertical bar represents mean ± SEM, n = 8 cells recorded. **p < 0.01 for the significance of difference from GABA only application (paired t-test).