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Effects of humulone on sleep latency, in seconds (s) and duration of sleep, in minutes (min) induced by pentobarbital sodium (35 mg/kg, i.p.) (A,B) and ethanol (3.5 g/kg, i.p.) (C,D) in mice. Each vertical bar represents the mean ± SEM, n = 6–7 mice/group. ***p < 0.001, **p < 0.01, *p < 0.05 for the significance of difference from the corresponding vehicle control group (One-way ANOVA followed by Dunnett’s post hoc test).
