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InRAGER2 lead profiling screen assay results. Primary assays were performed at 10 μM InRAGER2 to determine the percent inhibition; secondary dose response determined IC50 and Ki.
| Assay name | %Inhibition at 10 μM | Ki (μM) | IC50 (μM) |
|---|---|---|---|
| 5-HT2B receptor | 95 | 0.13 | 0.26 |
| Urotensin receptor | 85 | 1.0 | 1.4 |
| Translocator protein 18 kDa (TSPO) | 81 | 0.44 | 0.48 |
| Adenosine A3 receptor | 75 | 0.83 | 1.4 |
| Cyclooxygenase 1 | 72 | n.d.a | 12 |
n.d. = not determined.
