Table 2.
Thermodynamic parameters for indinavir-DNA interaction calculated using fluorescence titrations.
| Temperature | Kb (M−1) | ΔGo (kcal/mol) | ΔSo (cal/K/mol) | ΔHo (kcal/mol) |
|---|---|---|---|---|
| 297 K | 1.64 × 108 | −2.86 | −39.0 | −14.5 |
| 301 K | 6.04 × 107 | −2.70 | ||
| 305 K | 1.94 × 107 | −2.54 | ||
| 311 K | 2.14 × 106 | −2.31 |