Table 3.

Multivariate cox-regression model for patients after primary surgery and neoadjuvnat treatment.

	Primary surgery				Neoadjuvant treatment
	Hazard ratio	95% confidence interval		p value	Hazard ratio	95% confidence interval		p value
		Lower	Upper			Lower	Upper
Sex (male vs. female)	0.74	0.37	1.48	0.394	1.372	0.797	2.361	0.254
Age group (< 65yrs vs. > 65 yrs)	1.537	1.011	2.339	0.044	1.319	0.953	1.825	0.095
Tumor stage (pT1/2 vs. pT3/4)	2.057	1.208	3.504	0.008	0.922	0.593	1.433	0.718
Lymph node metastasis (pN0 vs. pN +)	3.641	2.228	5.951	< 0.001	2.571	1.771	3.732	< 0.001
Integrin alphaV expression (negative vs. positive)	2.031	1.102	3.741	0.023	0.951	0.618	1.464	0.819