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. 2020 Oct 27;11:5430. doi: 10.1038/s41467-020-19249-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a 5α-reduction reaction of the ∆^4,5 double bond of testosterone catalyzed by SRD5A2 to generate dihydrotestosterone (DHT). b SRD5A2 inhibition by finasteride and dutasteride. The two inhibitors share the same ring structure with different R-groups connected to the amide side chains. c–e Three views of the SRD5A2 structure. The NADP–DHF adduct was shown as spheres. L1–6 represent six loops connecting 7-TMs. The NADP and DHF moieties were colored in light cyan and light pink, respectively.