Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 27;11:5430. doi: 10.1038/s41467-020-19249-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Structural comparison of the transmembrane regions of SRD5A2 and MaSR1 (PDB ID: 4QUV). The core transmembrane regions in SRD5A2 and MaSR1 that can be structurally aligned are shown as colored ribbons, while the rest parts are shown as gray ribbons. The right panel shows the superimposition of SRD5A2 and MaSR1. b Occluded and exposed ligand-binding cavities in SRD5A2 and MaSR1, respectively. c Structural comparison of the transmembrane regions of SRD5A2 and ICMT (PDB ID: 5V7P). The core transmembrane region of ICMT that can be well aligned to SRD5A2 is colored orange. The cofactor of ICMT, SAH, is colored green. The right panel shows the superimposition of SRD5A2 and ICMT. The potential substrate entry ports in all three enzymes are indicated by arrows.