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. 2020 Oct 27;3:620. doi: 10.1038/s42003-020-01339-9

Fig. 7. Arl8b is essential for the increased tumor growth and metastasis in highly invasive cancer cells that survive IR in vivo.

Fig. 7

a Experimental scheme. IR-S cells were selected for 48 h before injection. b Tumor growth of 4T1-Luc xenografts in nude mice. Points and connecting lines, means; bars, SEMs. c Tumor sizes on day 32. Scatter plot, means (4 mice per group); bars, SEMs. *P < 0.05. d Sections from 4T1-Luc tumors were subjected to IHC staining with a antibody against Ki-67 (a marker of proliferation). Bar, 100 μm. e Ratio of Ki-67 positive cells. Columns, means (n = 4); bars, SEMs. *P < 0.05. f Metastasis of 4T1-Luc cells was detected by luminescence using IVIS. g Representative images of H&E-stained lung sections. Red asterisks (*) indicate metastatic nodules. Bar, 500 µm. h Analysis of lung metastasis. Scatter plot, means (4 mice per group); bars, SEMs. ***P < 0.001.