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. 2020 Oct 27;10:18351. doi: 10.1038/s41598-020-75186-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intrinsic leptin controls mucosal healing through LepR⁺ cryptal mesenchymal cells. (a) Body weight change (n = 4 per group). *P < 0.05. (b) Ratio of control and DSS treated mice colon length are shown. Data are shown as means ± SEM; *P < 0.05. (c) H and E staining of colon on day 6 of DSS treatment is shown. Scale bar, 100 μm. (d) Immunohistochemical analysis of DSS-treated mice on day 6. EdU was administered intraperitoneally 3 h before euthanasia. Tissues were stained with DAPI, EpCAM, and gp38 with detection of proliferated EdU⁺ cells. Representative data from 4 mice are shown. Scale bar, 100 μm. EdU⁺ cells counted in per crypt were shown. All data are representative of two independent experiments.