Figure 1.

BP and Vascular Mechanical Properties

Systolic (A,B) and diastolic (C,D) blood pressure (BP) measured by awake tail cuff readings at 20 and 30 weeks of age. Aortic strain measured at the mid-ascending aorta by high-frequency ultrasound at 20 (E) and 30 (F) weeks of age. Aortic distensibility measured at the mid-ascending aorta at 20 (G) and 30 (H) weeks of age. Values are mean ± SEM. ∗p < 0.05 versus wild-type (WT) mice and mice deficient for low-density lipoprotein receptor (LDL-R^−/−); ^†p < 0.05 versus LDL-R^−/− on a Western-style diet (WSD); ^‡p < 0.05 versus WT mice. All p values are post hoc (analysis of variance, p < 0.05) analysis with unpaired Student's t-tests. AD13^−/− = deficient for ADAMTS13.