Table 1.

Plasma Lipid Concentrations in Mice at 30 Weeks of Age

	WT (n = 6)	LDL-R−/− (n = 8)	LDL-R−/− + WSD (n = 8)	LDL-R−/− AD13−/− + WSD (n = 6)
Total cholesterol, mg/dl	56 ± 8	193 ± 57∗	999 ± 273†	1,000 ± 284†
HDL cholesterol, mg/dl†	38 ± 8	42 ± 14	62 ± 16	55 ± 16
LDL cholesterol, mg/dl	7 ± 2	114 ± 30∗	552 ± 167†	516 ± 180†
Triglycerides, mg/dl	35 ± 10	94 ± 58∗	697 ± 293†	690 ± 210†

Values are mean ± SD.

AD13^−/− = deficient for ADAMTS13; HDL = high-density lipoprotein; LDL = low-density lipoprotein; LDL-R^−/− = deficient for low-density lipoprotein receptor; WSD = Western-style diet; WT = wild type

^∗p < 0.01 versus WT mice;

^†p < 0.01 versus WT and LDL-R^−/− mice (corrected for multiple comparisons).