Table 3.
Results of simple cause-specific Cox regressions for hepatocellular carcinoma recurrence.
| HR | 95% CI | P value | |
|---|---|---|---|
| Age | 0.96 | 0.89-1.05 | 0.403 |
| Sex | |||
| Female | |||
| Male | 3.71 | 0.47-28.97 | 0.212 |
| Transplantation waiting time | 1.00 | 1.00-1.00 | 0.573 |
| Child-Pugh classification | |||
| Child-Pugh stage A | |||
| Child-Pugh stage B | 2.41 | 0.62-9.32 | 0.202 |
| Child-Pugh stage C | 0.50 | 0.05-4.81 | 0.549 |
| MELD score | 0.92 | 0.80-1.06 | 0.262 |
| Alpha-fetoprotein (ng/ml) × 100∗ | 1.00 | 0.99-1.01 | 0.746 |
| Received previous locoregional treatment for HCC | 1.28 | 0.37-4.37 | 0.695 |
| Number of HCC lesions | |||
| Single tumor | |||
| 2-3 tumors | 2.58 | 0.23-28.49 | 0.439 |
| 4-5 tumors | 9.05 | 0.81-100.45 | 0.073 |
| >5 tumors | 5.81 | 0.70-48.30 | 0.103 |
| Total tumor size | |||
| <5 cm | |||
| 5-9 cm | 3.76 | 0.62-22.64 | 0.149 |
| >9 cm | 3.04 | 0.76-12.15 | 0.116 |
| Incidental HCC diagnosed postoperatively | 1.13 | 0.33-3.87 | 0.842 |
| Microvascular invasion | 14.86 | 4.47-49.39 | <0.001 |
| Presence of tumor necrosis | 1.44 | 0.41-5.12 | 0.569 |
| >4 red blood cells units transfused during transplantation | 1.30 | 0.35-4.92 | 0.695 |
aThe results reported for alpha-fetoprotein levels correspond to increases of 100 units of alpha-fetoprotein levels; i.e., the hazard ratio of 1.01 means that every increase of 100 ng/ml is associated with a 1% increase in the hazard of hepatocellular carcinoma recurrence. HCC: hepatocellular carcinoma; MELD: model for end-stage liver disease.