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MiR-637 directly targeted USP21. (A) Schematic representation of the miR-637 site in USP21. (B) Luciferase reporter assay was operated to confirm the interaction between miR-637 and USP21. (C, D) MiR-637 mimics reduced USP21 levels in HCC cells. (E) The protein levels of USP21 in HCC tissues were measured by IHC. (F) USP21 expression in HCC explored by TCGA database. (G, H) High USP21 expression was linked to poor disease outcomes in HCC patients. *P < 0.05.
