Table 3.
The kinases, miRNAs, and transcription factors-target networks of RRM2 in LUAD
| Enriched category | Gene set | Leading edge number | NES | FDR |
|---|---|---|---|---|
| Kinase target | Kinase_CDK1 | 67 | 2.3829 | 0 |
| Kinase_PLK1 | 31 | 2.2374 | 0 | |
| Kinase_CDK2 | 84 | 2.2281 | 0 | |
| Kinase_AURKB | 31 | 2.1503 | 0 | |
| Kinase_ATM | 38 | 2.1011 | 0 | |
| miRNA Target | AGCGCTT,MIR-518F,MIR-518E,MIR-518A | 5 | -1.4072 | 0.48209 |
| CCCAGAG,MIR-326 | 30 | -1.4088 | 0.55154 | |
| AGGGCAG,MIR-18A | 34 | -1.4499 | 0.55987 | |
| GAGCTGG,MIR-337 | 34 | -1.2417 | 0.61109 | |
| ACACTGG,MIR-199A,MIR-199B | 36 | -1.3139 | 0.61239 | |
| Transcription Factor | V$E2F_Q6 | 87 | 2.1966 | 0 |
| V$E2F_Q4 | 87 | 2.1905 | 0 | |
| V$E2F1_Q6 | 91 | 2.1891 | 0 | |
| V$E2F4DP1_01 | 91 | 2.1752 | 0 | |
| V$E2F1DP1_01 | 90 | 2.1731 | 0 |
LUAD: Lung adenocarcinoma; NES: normalized enrichment score; FDR: false discovery rate.