Table 2.
Differential metabolites related to capecitabine related AE
| Metabolites | HFS | Anemia | Neutropenia | Thrombocytopenia | BMS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FOCa | AUC (95% CI)b | P-valueb | FOCa | AUC (95% CI)b | P-valueb | FOCa | AUC (95% CI)b | P-valueb | FOCa | AUC (95% CI)b | P-valueb | FOCa | AUC (95% CI)b | P-valueb | |
| Methionine | -1.738 | 0.731 (0.569-0.893) | 0.029* | -1.208 | 0.612 (0.418-0.807) | 0.281 | -1.268 | 0.592 (0.398-0.785) | 0.355 | 1.083 | 0.543 (0.347-0.739) | 0.665 | -1.198 | 0.557 (0.354-0.759) | 0.594 |
| 5-acetamidovalerate | -1.603 | 0.716 (0.554-0.878) | 0.042* | -3.994 | 0.902 (0.784-1.000) | <0.001* | -1.620 | 0.719 (0.546-0.891) | 0.027* | 1.117 | 0.553 (0.359-0.748) | 0.594 | -1.382 | 0.625 (0.438-0.812) | 0.241 |
| Methylhistidine | 1.182 | 0.541 (0.330-0.751) | 0.701 | -1.595 | 0.754 (0.551-0.956) | 0.015* | -1.477 | 0.650 (0.465-0.836) | 0.129 | 1.342 | 0.573 (0.381-0.766) | 0.463 | 1.011 | 0.545 (0.342-0.749) | 0.670 |
| N-Acetylaminooctanoic acid | -1.926 | 0.631 (0.451-0.811) | 0.215 | -1.781 | 0.732 (0.548-0.915) | 0.026* | 1.049 | 0.510 (0.309-0.711) | 0.921 | 1.172 | 0.633 (0.447-0.820) | 0.182 | -1.185 | 0.511 (0.308-0.715) | 0.915 |
| N-Acetylleucine | -1.174 | 0.531 (0.304-0.759) | 0.768 | -2.266 | 0.583 (0.391-0.775) | 0.424 | -1.405 | 0.797 (0.652-0.943) | 0.003* | -1.125 | 0.590 (0.398-0.782) | 0.368 | -1.529 | 0.674 (0.488-0.861) | 0.102 |
| Indoleacetic acid | -1.326 | 0.625 (0.425-0.825) | 0.238 | -1.616 | 0.786 (0.601-0.971) | 0.006* | 4.286 | 0.598 (0.402-0.794) | 0.322 | 2.210 | 0.513 (0.315-0.712) | 0.894 | 2.618 | 0.655 (0.467-0.843) | 0.145 |
| 1-Methyl-2-nonyl-4(1H)-quinolinone | -1.773 | 0.684 (0.497-0.872) | 0.081 | -2.907 | 0.841 (0.631-1.000) | 0.001* | -2.017 | 0.752 (0.585-0.918) | 0.011* | -1.310 | 0.543 (0.349-0.738) | 0.665 | -1.880 | 0.693 (0.518-0.868) | 0.070 |
| Hydroxyphenylacetylglycine | 1.816 | 0.647 (0.441-0.853) | 0.165 | 6.386 | 0.507 (0.281-0.734) | 0.945 | 3.181 | 0.667 (0.483-0.850) | 0.092 | 2.637 | 0.700 (0.526-0.874) | 0.046* | 2.192 | 0.670 (0.493-0.848) | 0.110 |
| Creatinine | -1.219 | 0.575 (0.368-0.782) | 0.478 | -1.662 | 0.707 (0.521-0.892) | 0.048* | -1.530 | 0.709 (0.533-0.885) | 0.035* | -1.125 | 0.690 (0.511-0.869) | 0.057 | -1.308 | 0.705 (0.504-0.905) | 0.055 |
| Indolylacryloylglycine | -7.358 | 0.716 (0.539-0.892) | 0.042* | -2.399 | 0.667 (0.466-0.867) | 0.110 | -2.125 | 0.552 (0.357-0.748) | 0.597 | -1.153 | 0.567 (0.363-0.770) | 0.505 | -1.409 | 0.595 (0.369-0.820) | 0.374 |
| 3,4-Methylenesebacic acid | -1.343 | 0.634 (0.418-0.851) | 0.204 | -3.602 | 0.826 (0.681-0.972) | 0.002* | -1.969 | 0.752 (0.587-0.916) | 0.011* | -1.259 | 0.547 (0.352-0.741) | 0.641 | -1.808 | 0.674 (0.493-0.856) | 0.102 |
| 2-trans,4-cis-Decadienoylcarnitine | -1.488 | 0.678 (0.490-0.867) | 0.092 | -1.705 | 0.703 (0.503-0.903) | 0.052 | -1.775 | 0.716 (0.540-0.891) | 0.029* | -1.064 | 0.530 (0.332-0.728) | 0.764 | -1.395 | 0.580 (0.383-0.776) | 0.456 |
| N1,N12-Diacetylspermine | -2.605 | 0.731 (0.501-0.962) | 0.029* | 1.557 | 0.500 (0.298-0.702) | 1.000 | 1.073 | 0.578 (0.386-0.771) | 0.428 | -2.621 | 0.563 (0.365-0.762) | 0.527 | -1.256 | 0.561 (0.352-0.770) | 0.570 |
| Hippurate | -3.304 | 0.65 (0.451-0.849) | 0.156 | -2.456 | 0.710 (0.524-0.896) | 0.044* | -1.737 | 0.526 (0.326-0.726) | 0.792 | -1.507 | 0.507 (0.310-0.703) | 0.947 | -1.997 | 0.591 (0.391-0.79) | 0.394 |
| Aspartylphenylalanine | -1.377 | 0.619 (0.404-0.834) | 0.262 | -1.924 | 0.717 (0.518-0.916) | 0.037* | -1.224 | 0.565 (0.372-0.758) | 0.509 | -1.141 | 0.543 (0.350-0.737) | 0.665 | -1.331 | 0.580 (0.382-0.777) | 0.456 |
| Phenylacetylglutamine | -1.421 | 0.684 (0.497-0.872) | 0.081 | -1.938 | 0.841 (0.631-1.000) | 0.001* | -1.619 | 0.752 (0.585-0.918) | 0.011* | -1.402 | 0.543 (0.349-0.738) | 0.665 | -1.689 | 0.693 (0.518-0.868) | 0.070 |
| Ubiquinone-1 | -1.862 | 0.684 (0.471-0.897) | 0.081 | -3.688 | 0.793 (0.617-0.970) | 0.005* | -2.499 | 0.771 (0.609-0.933) | 0.006* | -1.613 | 0.590 (0.386-0.794) | 0.368 | -2.238 | 0.689 (0.488-0.891) | 0.076 |
| 4-Pyridoxic acid | 3.222 | 0.744 (0.550-0.938) | 0.021* | 2.362 | 0.754 (0.592-0.915) | 0.015* | -1.350 | 0.546 (0.342-0.750) | 0.644 | -1.082 | 0.590 (0.384-0.796) | 0.368 | 1.936 | 0.739 (0.529-0.948) | 0.025* |
| Indoxyl | -1.141 | 0.675 (0.500-0.850) | 0.098 | -1.553 | 0.859 (0.663-1.000) | 0.001* | -1.455 | 0.637 (0.446-0.828) | 0.166 | -1.473 | 0.553 (0.358-0.749) | 0.594 | -1.928 | 0.614 (0.425-0.803) | 0.286 |
aFOC was calculated from the arithmetic mean values. FOC with a positive value means a relative higher concentration in CRC patients, while a negative value indicates a relative lower concentration as compared to controls. bAUC and p value was obtained by ROC curve analysis. *P-value < 0.5 is considered to have statistical significance. Abbreviations: FOC, Fold of changes. AUC, area under the curve.