Table 4.
Metabolic pathway enrichment analysis based on capecitabine-related-adverse-effect related metabolites
| Pathway | Source | External_id | P-value | Matched metabolite |
|---|---|---|---|---|
| Conjugation of carboxylic acids | Reactome | R-HSA-159424 | 0.0007 | Hippurate, Alpha-N-Phenylacetyl-L-glutamine, |
| Amino Acid conjugation | Reactome | R-HSA-156587 | 0.0007 | Hippurate, Alpha-N-Phenylacetyl-L-glutamine, |
| Glucose Homeostasis | Wikipathways | WP661 | 0.0016 | Methionine, Hippurate, |
| Trans-sulfuration pathway | Wikipathways | WP4253 | 0.0027 | Methionine, Creatinine, |
| Vitamin B12 Metabolism | Wikipathways | WP1533 | 0.0077 | Methionine, Creatinine, |
| Phenylalanine metabolism - Homo sapiens (human) | KEGG | path:hsa00360 | 0.0181 | Hippurate, Alpha-N-Phenylacetyl-L-glutamine, |
| Arginine and proline metabolism - Homo sapiens (human) | KEGG | path:hsa00330 | 0.0211 | Creatinine, 4-Acetamidobutanoic acid, |
| Tryptophan metabolism - Homo sapiens (human) | KEGG | path:hsa00380 | 0.0226 | Indoleacetic acid, Indoxyl, |
| Amino Acid metabolism | Wikipathways | WP3925 | 0.0367 | Methionine, Indoleacetic acid, |
| Phase II - Conjugation of compounds | Reactome | R-HSA-156580 | 0.0468 | Hippurate, Alpha-N-Phenylacetyl-L-glutamine, |
Metabolic pathway enrichment analysis was carried by an on-line tool (CPDB, http://cpdb.molgen.mpg.de/). The pathway databases for matching included REACTOME, KEGG, SMPDB, and Wikipathways. The minimum overlap with input list was set as 2 and the p-value cutoff was set as 0.05.