Table 3.
Multivariate analysis of prognostic factors using the Cox- regression model (including biologic factors)
| Variables | HR | 95%CI | P |
|---|---|---|---|
| Age (years) | |||
| <50 | 1 | ||
| ≥50 | 1.345 | 1.087-1.665 | 0.006 |
| Race/ethnicity | |||
| Non-Hispanic White | 1 | ||
| Non-Hispanic Black | 1.419 | 1.140-1.766 | 0.002 |
| Hispanic (All Races) | 1.075 | 0.813-1.421 | 0.613 |
| Other | 0.917 | 0.656-1.283 | 0.613 |
| Histological subtype | |||
| Infiltrating ductal carcinoma | 1 | ||
| Invasive lobular carcinoma | 1.342 | 0.931-1.935 | 0.115 |
| Other | 1.048 | 0.833-1.319 | 0.688 |
| T category | |||
| T1 | 1 | ||
| T2 | 0.984 | 0.670-1.445 | 0.933 |
| T3 | 1.106 | 0.741-1.652 | 0.621 |
| T4 | 1.574 | 1.097-2.258 | 0.014 |
| Tx | 1.917 | 1.134-3.242 | 0.015 |
| M category | |||
| M0 | 1 | ||
| M1 | 2.570 | 2.055-3.214 | <0.001 |
| Histological grade | |||
| Well differentiated | 1 | ||
| Moderately differentiated | 1.185 | 0.677-2.072 | 0.553 |
| Poorly/undifferentiated | 1.385 | 0.797-2.406 | 0.248 |
| Unknown | 0.244 | 0.128-0.464 | <0.001 |
| ER status | |||
| Negative | 1 | ||
| Positive | 0.661 | 0.517-0.845 | 0.001 |
| Unknown | 0.825 | 0.309-2.203 | 0.701 |
| PR status | |||
| Negative | 1 | ||
| Positive | 0.680 | 0.532-0.869 | 0.002 |
| Unknown | 1.275 | 0.579-2.805 | 0.546 |
| HER2 status | |||
| Negative | 1 | ||
| Positive | 0.531 | 0.429-0.657 | <0.001 |
| Unknown | 0.752 | 0.476-1.188 | 0.222 |
HR, hazard ratio; CI, confidence interval; T, tumor; M, distant metastasis; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.