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. 2020 Aug 12;123(9):1437–1444. doi: 10.1038/s41416-020-1024-2

Fig. 2. Illustration of dEGFR39 distribution in the three reactions and output data from digital PCR in the form of a 2D histogram.

Fig. 2

a 19DelWT molecules are double positive (CY5+/HEX+), and the rest of the signals in the HEX and CY5 channels are generated by 19DelMU (CY5−/HEX+) and S768IMU (CY5+/HEX−), respectively. The signals in the FAM channel are generated by L858RMU. b 20insWT molecules are double positive (CY5+/HEX+), and the rest of the signals in the HEX and CY5 channels are generated by G719XMU (CY5−/HEX+) and 20insMU (CY5+/HEX−), respectively. c The blue and green dots represent the signal of T790M and C797S in trans configuration with T790M, respectively. The double positive represents C797S in cis configuration with T790M.