Table 1.
Analysis accuracy of EGFR L858R, 19Del and T790M in dEGFR39 assay was determined by testing the DNA Reference Standards.
| 19Del | L858R | T790M | |
|---|---|---|---|
| Expected mutant ratio | 12.50% | 12.50% | 12.50% |
| Measured mean ± SD | 12.63 ± 1.05% | 12.13 ± 0.97% | 12.19 ± 1.03% |
| CV | 0.08 | 0.08 | 0.08 |
| Paired t-Test | |||
| P-value (vs. Expected) | 0.70 | 0.24 | 0.36 |
| Significantly different (P < 0.05) | NO | NO | NO |
| Bland–Altman analysis | |||
| Bias ± SD | 0.13 ± 1.05% | 0.37 ± 0.97% | 0.31 ± 1.03% |
| 95% CI | −0.57 to 0.83% | −1.53 to 2.27% | −1.71 to 2.33% |
SD standard deviation, CV coeffiency variation, CI confidence interval.