Table 3.
Concordance of dEGFR39 for plasma EGFR mutations compared to ARMS.
| Mutant type | Patient count | PPA (95% CI) |
NPA (95% CI) |
OPA (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| TP | FN | TN | FP | ||||
| L858R/L861Q | 6 | 0 | 26 | 1 |
100 60.97–100% |
96.29 81.72–99.34% |
96.97 84.68–99.46% |
| S768I | 7 | 1 | 25 | 0 |
85.71 52.91–97.76% |
100 86.68–100% |
96.97 84.68–99.46% |
| G719X | 1 | 0 | 32 | 0 |
100 20.65–100% |
100 89.28–100% |
100 89.57–100% |
| 19Del | 0 | 0 | 33 | 0 | NA |
100 89.57–100% |
100 89.57–100% |
| 20ins | 1 | 0 | 32 | 0 |
100 20.65–100% |
100 89.28–100% |
100 89.57–100% |
| T790M | 3 | 0 | 28 | 2 |
100 43.85–100% |
93.33 78.68–98.15% |
93.94 80.39–98.32% |
| Overall | 15 | 1 | 14 | 3 |
9375.00 71.67–98.89% |
82.35 58.97–93.81% |
87.88 72.67–95.18% |
TP true positive, FN false negative, TN true negative, FP false positive, PPA positive predict agreement, NPA negative predict agreement, OPA overall predict agreement, CI confidence interval.