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The input for the PRosettaC protocol. A. The chemical structure of a BRD4 PROTAC molecule including a CRBN ligand (thalidomide), a BRD4 ligand (JQ1), and an alkane linker. B. Structure of CRBN with thalidomide. C. Structure of BRD4 with JQ1. D. Thalidomide with the anchor atom marked. E. JQ1 with the anchor atom marked. All structures are based on PDB: 6BOY.
