Table 2.

Incidence rates and excess of cases of breast cancer compared with never use per 10 000 women years by different age categories and different durations and recency of hormone replacement therapy (HRT) use

HRT and duration of use by recency	Age group (years)
	50-59		60-69		70-79
	Rate per 10 000	Extra cases	Rate per 10 000	Extra cases	Rate per 10 000	Extra cases
Never use	26	–	31	–	30	–
Oestrogen only:
Recent use 1-5 years	29	3	35	4	38	8
Recent use ≥5 years	28	–	36	5	38	8
Oestrogen-progestogen:
Past use 1-5 years	25	–	33	2	35	5
Past use ≥5 years	24	–	36	5	38	8
Recent use 1-<5 years	35	9	46	15	49	19
Recent use ≥5 years	41	15	57	26	66	36
Tibolone:
Recent use 1-<5 years	28	–	35	4	38	8
Recent use ≥5 years	31	–	40	9	45	15

Rates were estimated using rates in unexposed populations from Clinical Practice Research Datalink multiplied by adjusted odds ratios derived from subgroup analyses for different age categories (see fig 5). Extra cases were reported only for statistically significant findings. Recent use is within one and five years; past use is five years before the index date.