Table 3.
Analysis of risk factors for the primary outcome measure (aggregate incidence of pancreatic fistula/leak/abscess) across all study participants (N = 800) via univariable logistic regression. ASA, American Society of Anesthesiologists; BMI, body mass index; C.I, confidence interval; Ref., reference statistics.
| Characteristic | Incidence/Number at Risk (%) | Odds Ratio | 95% C.I. | p-value |
|---|---|---|---|---|
| Treatment Cohort | ||||
| Pasireotide | 87/652 (13.3) | 0.58 | [0.37 – 0.92] | 0.020 |
| Placebo | 31/148 (20.9) | |||
| ASA Score | ||||
| 1-2 | 36/268 (13.4) | Ref. | ||
| 3 | 79/507 (15.6) | 1.19 | [0.78 – 1.82] | 0.71 |
| 4 | 3/23 (13.0) | 0.97 | [0.27 – 3.42] | |
| Gender | ||||
| Female | 69/401 (17.2) | 1.48 | [1.00 – 2.21] | 0.050 |
| Male | 49/399 (12.3) | Ref. | ||
| Resection | ||||
| Distal pancreatectomy | 40/259 (15.4) | 1.08 | [0.72 – 1.64] | 0.70 |
| Whipple | 78/541 (14.4) | Ref. | ||
| Gland Texture | ||||
| Soft | 78/467 (16.7) | 1.48 | [0.98 – 2.24] | 0.06 |
| Firm | 39/327 (11.9) | Ref. | ||
| Duct Size | ||||
| > 4 mm | 40/353 (11.3) | 0.60 | [0.40 – 0.91] | 0.015 |
| ≤ 4 mm | 78/445 (17.5) | Ref. | ||
| Age at Surgery, years | 118/800 (14.8) | 0.99 | [0.98 – 1.01] | 0.20 |
| BMI, kg/m2 | 107/745 (14.4) | 1.05 | [1.01 – 1.09] | 0.007 |