Table 3.
Average Connectivity Within Network.
| Network Connectivity (Z-Score) |
Control N = 20 |
SCD N = 40 |
P-Value | Parameter Estimate for SCD Cohort [95% Confidence Interval] |
|---|---|---|---|---|
| Cortical Sensory-Motor Networks | ||||
| Sensory-Motor | 0.784 [0.741, 0.869] | 0.638 [0.461, 0.798] | 0.004* | −0.177 [−0.289, −0.065] |
| Sensory-Motor Lateral | 0.313 [0.297, 0.389] | 0.284 [0.236, 0.322] | 0.014* | −0.055 [−0.097, −0.013] |
| Auditory | 0.398 [0.368, 0.444] | 0.307 [0.259, 0.399] | 0.004* | −0.084 [−0.138, −0.030] |
| Visual | 0.322 [0.283, 0.428] | 0.316 [0.254, 0.400] | 0.171 | −0.035 [−0.087, 0.017] |
| Cortical Association Networks | ||||
| Cerebellar | 0.366 [0.272, 0.390] | 0.348 [0.294, 0.438] | 0.780 | 0.009 [−0.059, 0.078] |
| Dorsal Attention | 0.248 [0.198, 0.316] | 0.275 [0.226, 0.323] | 0.394 | 0.020 [−0.027, 0.067] |
| Ventral Attention | 0.227 [0.168, 0.263] | 0.234 [0.163, 0.285] | 0.650 | 0.011 [−0.038, 0.059] |
| Memory | 0.353 [0.252, 0.549] | 0.322 [0.267, 0.451] | 0.407 | −0.037 [−0.127, 0.054] |
| Default Mode | 0.181 [0.159, 0.222] | 0.176 [0.141, 0.217] | 0.239 | −0.018 [−0.048, 0.013] |
| Salience | 0.332 [0.287, 0.399] | 0.246 [0.194, 0.332] | 0.004* | −0.074 [−0.122, −0.027] |
| Cingulo-Opercular | 0.442 [0.342, 0.542] | 0.371 [0.299, 0.455] | 0.026 | −0.074 [−0.138, −0.010] |
| Fronto-Parietal | 0.211 [0.172, 0.272] | 0.167 [0.149, 0.221] | 0.030 | −0.032 [−0.060, −0.003] |
| Subcortical Network | ||||
| Subcortical | 0.361 [0.285, 0.428] | 0.302 [0.265, 0.344] | 0.011* | −0.064 [−0.112, −0.016] |
Raw p-values reported. Parameter estimates for the SCD cohort describe the change for SCD participants compared to controls in functional connectivity (average Z-score) within each network while controlling for family relationship.
*
Statistically significant after Benjamini-Hochberg procedure.