FIG 2.

RUNX CBSs are found more frequently than would be expected by chance across herpesviruses but less frequently in nonherpesviruses. (A) Expected and observed numbers of RUNX CBSs across human and nonhuman herpesviruses. (B) Expected and observed numbers of RUNX CBSs across major nonherpesviruses. Expected numbers were calculated accounting for each genome’s GC content. (C) Percent difference of observed from expected numbers of RUNX CBS calculated for each evaluated virus. The data are means ± the SE. ***, P < 0.001 (versus nonherpesviruses assessed by the Student t test). In addition to being significantly different compared to each other, the herpesvirus difference is significantly greater than zero (P = 0.01), while the nonherpesvirus difference is significantly less than zero (P = 0.02).