TABLE 5.
Panel of viral isolates used in neutralization assays
| Isolate | Genotype | Neutralization phenotypea | Neutralization resistance ranka | % identity with:b
|
|
|---|---|---|---|---|---|
| H77C sE2 | H77C ΔHVR1 | ||||
| H77 | 1a | Moderate | 22 | 100 | 100 |
| UKNP1.18.1 | 1b | Resistant | 3 | 79 | 82 |
| UKNP1.20.3 | 1b | Moderate | 32 | 79 | 82 |
| UKNP2.4.1 | 2a | Resistant | 1 | 72 | 74 |
| UKNP2.1.2 | 2i | Moderate | 23 | 70 | 73 |
| UKNP4.1.1 | 4a | Resistant | 2 | 71 | 75 |
| J6 | 2a | Resistant | 11 | 71 | 74 |
a
Neutralization phenotype and neutralization resistance rank were based on assessment of 78 HCVpp with a panel of monoclonal antibodies by Urbanowicz et al. (40).
b
Percent amino acid sequence identity with H77C sE2 (aa 384 to 661) and ΔHVR1 (aa 408 to 661).