FIG 4.

The extrinsic death pathways are not involved in HIV-induced CD4 T-cell apoptosis in vitro. (A) Av and 7AAD levels on SupT1 cells with HIV infection and RAL treatment in the presence of anti-CD178, anti-CD40, and anti-CD253 blocking or isotype control antibodies. (B) Av and 7AAD levels in primary CD4 T cells with or without HIV infection, in the presence of anti-CD178, anti-CD40, and anti-CD253 blocking or isotype control antibodies for 5 days (n = 3). (C) Av and 7AAD levels in SupT1 cells treated with an α-CD95 (Fas) in the presence or absence of α-CD178 blocking antibodies.