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. 2020 Oct 27;94(22):e01301-20. doi: 10.1128/JVI.01301-20

FIG 3.

FIG 3

Comparison of S1-CTD domains from SADS-CoV, SARS-CoV, HCoV-NL63, and SARS-CoV-2. (A) Sequence alignment of S1-CTDs from SADS-CoV, SARS-CoV, SARS-CoV-2, and HCoV-NL63. (B to D) Structures of SARS-CoV-2 S1-CTD (B), SARS-CoV S1-CTD (C), and NL63-CoV S1-CTD (D) in complex with ACE2. CTDs are in green, and ACE2 is in gray. (E) Structural alignment of SARS-CoV-2 (gray and red), SARS-CoV (gray and purple), and SADS-CoV S1-CTD (green). Red and purple ribbons indicate the ACE2-binding motifs (insertion domains) of SARS-CoV-2 and SARS-CoV, respectively.