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. 2020 Oct 24;11:2041731420954712. doi: 10.1177/2041731420954712

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — Characterisation of hMSC-endothelial cell interactions using the microfluidic device. (a) Extracellular fibronectin deposition by hMSCs was assessed after 7 days under perfusion and (b) a tendency of greater deposition in response to CoO 0% was observed. (c) Representative images showing HUVEC attachment to hMSC-microsphere material. Quantification indicated that (d) HUVEC attachment to 7 day hMSC-microsphere cultures after 24 h was increased on CoO 0% PG microspheres compared to CoO 2% PG microspheres in downstream chambers (4–5), associated with corresponding fibronectin deposition (e). (f) Extended culture of HUVECs on the hMSC-microspheres for a further 48 h (to a total of 3 days culture) revealed interactions between HUVECs and the hMSC-microsphere clusters including limited formation of tubule-like structures (indicated by arrows). For (b) Mean ± SD, n = 4; For (d and e), pooled data from two independent experiments are shown as Mean ± SD, n = 2. Scale bars = 500 µm.