Fig. 2.

Knockdown of circ_0001421 repressed LC cell proliferation, migration, invasion and glycolysis in vitro. H1299 and A549 cells were transfected with si-NC or si-circ_0001421. a Circ_0001421 expression was measured by qRT-PCR. b MTT assay was performed to assess cell proliferation. c-d Cell migration and invasion were determined by Transwell assay. e-f Glucose consumption and lactate production were examined by a Glucose assay kit and a Lactic Acid assay kit. g Western blot was performed to measure the protein expression of HK2. *P < 0.05