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. 2020 Oct 14;11:591713. doi: 10.3389/fimmu.2020.591713

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Copyright © 2020 Sasaki, Otsuka, Arimochi, Tsukumo and Yasutomo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1β– and Il-18–mediated inflammation in Nlrc4-H443P-Tg mice. (A) Total neutrophil numbers in the spleens of control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/−, Nlrc4-H443P-Tg/Il18^−/−, and Nlrc4-H443P-Tg/Il1b^−/−Il18^−/− mice at the age of 8 and weeks were determined (N = 8 in each group). The neutrophils were defined as CD11b+Gr-1^high cells. The data are shown as the mean ± SD. *P < 0.05; **P < 0.01. (B) Total neutrophil, T cells or B cells numbers in the spleens of control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/−, Nlrc4-H443P-Tg/Il18^−/−, and Nlrc4-H443P-Tg/Il1b^−/−Il18^−/− mice at the age of 20 weeks were determined (N = 8 in each group). The data are shown as the mean ± SD. *P < 0.05; **P < 0.01. Serum (C) IL-18 was measured in control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/− and Nlrc4-H443P-Tg/Il18^−/− mice at the age of 20 weeks (N = 5 in each group), and serum (D) G-CSF was measured in control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/−, Nlrc4-H443P-Tg/Il18^−/−, and Nlrc4-H443P-Tg/Il1b^−/−Il18^−/− mice at the age of 20 weeks (N = 5 in each group). Data are shown as the mean ± SD. **P < 0.01.