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. 2020 Oct 14;11:591713. doi: 10.3389/fimmu.2020.591713

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Copyright © 2020 Sasaki, Otsuka, Arimochi, Tsukumo and Yasutomo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1β– and Il-18–mediated inflammation in the skin and joints of Nlrc4-H443P-Tg mice. (A) Histological sections of ear skin and ankle joints in control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/−, Nlrc4-H443P-Tg/Il18^−/−, and Nlrc4-H443P-Tg/Il1b^−/−Il18^−/− mice at the age of 20 weeks were stained with hematoxylin and eosin. (B) The histological scores were evaluated in the ear skin and ankle joints in in control, Nlrc4-H443P-Tg, Nlrc4-H443P-Tg/Il1b^−/−, Nlrc4-H443P-Tg/Il18^−/−, and Nlrc4-H443P-Tg/Il1b^−/−Il18^−/− mice at the age of 20 weeks (N = 8 in each group). Data are shown as the mean ± SD. *P < 0.05, **P < 0.01.