Figure 6.

Breast images obtained in a patient with a Triple Negative subtype breast cancer in the left breast (same patient from Figure 1): baseline pre-neoadjuvant chemotherapy, early after two cycles and pre-surgery after eight cycles. Slices from baseline, early (after two cycles) and pre-surgical (after eight cycles) DTI in the top row. Corresponding slices (bottom row) from baseline post-contrast image, T ₂ weighted image after two cycles and post-contrast image after eight cycles, pre-surgery. Note that in the DTI images after two cycles, there is a functional qualitative partial major almost complete response whilst in the corresponding T ₂ weighted image, the morphologic response is minor or minimal. When comparing the DTI images after eight cycles with the corresponding DCE image, there is a complete response in the DTI images (arrow, top row) and a residual enhancement in the DCE images (arrow, bottom row) interpreted as partial major response. The final pathology confirmed a complete response that was already predicted by the early DTI exam after two cycles. DCE, dynamic contrast-enhanced; DTI, diffusion tensor imaging.