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. 2020 Oct 28;20:171. doi: 10.1186/s12894-020-00738-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overview of patient case study. a Serum PSA concentration over 10 year course of disease with ultrasound-guided sextant core biopsy results (inset). Numbers indicate dominant Gleason grade in each core with length of tumour involvement indicated in millimetres. Primary disease and relapsed castration resistant disease periods indicated with histopathological classification indicated. b Types of duration of treatments performed. HDRBT: high dose-rate brachytherapy, EBRT: external beam radiation therapy, TURP: transurethral resection of prostate. PNI: Perineural invasion. GGG: Gleason Grade Group, PZ: peripheral zone, TZ: transition zone