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. 2020 Oct 28;20:171. doi: 10.1186/s12894-020-00738-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Immuno-transcriptomic profiling reveals steady progression to immune-excluded phenotype. a Two-colour (pink and brown) DAB staining of the T cell marker CD3 (brown) and lymphocyte marker CD45 (pink) in four biopsies in tumour stroma and tumour zones. Scale bar indicates 100 µm. Quantification of b CD3+ and c CD45+ CD3- cell densities (per mm²) in each biopsy core tissue zone. Major treatments shown below. d Transcriptomic and proteomic analysis of immune cell marker expression changes over course of disease. Shaded areas indicates two-fold change threshold