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. 2020 Oct 28;20:171. doi: 10.1186/s12894-020-00738-8

Table 2.

Known genomic drivers of NEPC

Gene Product References
RB1 RB Transcriptional Corepressor 1 [1921]
PTEN Phosphatase and tensin homolog [20]
CHD1 Chromodomain Helicase DNA Binding Protein 1 [19]
TP53 Tumor Protein P53 [19, 21]
BRCA2 BRCA2 DNA Repair Associated [19]
AR Androgen Receptor [19, 22]
SPOP Speckle Type BTB/POZ Protein [19]
TMC8 Transmembrane Channel Like 8 [19]
FOXA1 Forkhead Box A1 [19]
LTBP1 Latent Transforming Growth Factor Beta Binding Protein 1 [19]
CRY1 Cryptochrome Circadian Regulator 1 [19]
BRAF B-Raf Proto-Oncogene, Serine/Threonine Kinase [19]
MYC MYC Proto-Oncogene, BHLH Transcription Factor [22, 23]
ERG ETS Transcription Factor ERG [24]
AURKA Aurora Kinase A [22]
E2F1 E2F Transcription Factor 1 [25]
ATR ATR Serine/Threonine Kinase [26]
MTOR Mechanistic Target Of Rapamycin Kinase [27]
EZH2 Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit [22, 28]
PEG10 Paternally Expressed 10 [29]