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. 2020 Oct 28;39:226. doi: 10.1186/s13046-020-01729-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Detail of chromosomes 1 (a), 4 (b), 9 (c) and 11 (d) profiles of samples derived from SK-N-BE(2) cell line, as examples of clonal evolution. The color and intensity of each probe denotes whether it is gained (blue) or lost (red). a 1p-(pter-21.3) is present in all samples except those from RAG1^−/−VN^+/+ mice where it is substituted by CNLOH. 1p(21.3–12) is gained or lost in some samples with different percentage of affected cells. +1q(21.3-ter) is shown in many of the hydrogels in a very low cell percentage, and is clearly observed in those with high AlgMA percentage and longest culture times, and also in samples from VN-KO mice. b P2 and P3 tumors from VN-KO mice had a typical 4p-(ter-15.2). c The percentage of clones affected with FSCAs and SCA of chromosome 9 are shown in a high proportion in the stiffest and long-time culture hydrogels and in VT-KO tumors, but not in VN-WT tumors. d +11q(13.1-qter) was negative selected in tumors from VN-KO mice and in stiff and long culture-time hydrogels. All chromosome profile representations were obtained with Nexus 10.0 software