Table 3.
Patient toxicity, stratified by T2DM group.
| T2DM group | RTOG toxicity, grade 2-4 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Early, incidence | GU | GI | |||||||||
| N | % | % | n | p-val | % | n | p-val | ||||
| I | No T2DM | 2603 | 81 | 26 | 688 | Ref | 5 | 146 | Ref | ||
| II | Metformin | 251 | 7.8 | 28 | 76 | 0.19 | 7 | 18 | 0.31 | ||
| III | Non-metformin oral antihyperglycemic | 148 | 4.6 | 21 | 32 | 0.20 | 4 | 6 | 0.42 | ||
| IV | Any insulin | 89 | 2.8 | 38 | 34 | 0.01 | 12 | 11 | 0.01 | ||
| V | T2DM, no meds | 126 | 3.9 | 22 | 28 | 0.29 | 9 | 11 | 0.14 | ||
| Late, KM at 3 years | |||||||||||
| N | % | % | 95% CI | p-val | % | 95% CI | p-val | ||||
| I | No T2DM | 2603 | 81 | 2.5 | 1.9 | 3.3 | Ref | 5.9 | 5.0 | 7.0 | Ref |
| II | Metformin | 251 | 7.8 | 2.1 | 0.8 | 5.6 | 0.25 | 6.1 | 3.5 | 10.5 | 0.42 |
| III | Non-metformin oral antihyperglycemic | 148 | 4.6 | 4.8 | 2.2 | 10.4 | 0.18 | 7.8 | 4.2 | 14.0 | 0.49 |
| IV | Any insulin | 89 | 2.8 | 11.4 | 5.5 | 22.6 | 0.001 | 13.7 | 7.6 | 24.1 | 0.01 |
| V | T2DM, no meds | 126 | 3.9 | 11.9 | 6.3 | 21.9 | 0.001 | 13.9 | 8.4 | 22.5 | 0.001 |
Abbreviations: CI: confidence interval; KM: Kaplan-Meier; RTOG: Radiation Therapy Oncology Group; sHR: sub hazard ratio