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Correlation of P1NP and BMD in denosumab-naïve patients. Dots show the absolute change in P1NP at 3 months versus the percentage change in BMD at 6 months and the line shows the average trend by using locally weighted regression (loess) with a span (degree of smoothing) of 0.85. Spearman's rho was −0.484 for total hip and −0.388 for lumbar spine. P1NP, procollagen-1 N-terminal propeptide; BMD, bone mineral density.
