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. 2020 Oct 28;15(10):e0240896. doi: 10.1371/journal.pone.0240896

Fig 1. Dalcinonacog alfa has three substitutions: R318Y/R338E/T343R.

Fig 1

Structural representation of the three substitutions in dalcinonacog alfa modeled onto PDB 1RFN [38]. The three amino acid substitutions are shown as red spheres and found in two conserved loops within the serine protease domain for FIX, namely R318Y located in the ‘150-loop’ provides resistance to inhibition by antithrombin, R338E and T343R, both located in the ‘170-loop’, provide enhanced procoagulant activity and affinity for activated FVIII.