Table 1. Genes associated with ACE2 mRNA expression in selected human tissues.
Derived from GTEx bulk RNA-Seq data [39].
| Tissue | Correlated_gene | Correlation | p-value | HGNC | UniProt | Description | Panther protein class |
|---|---|---|---|---|---|---|---|
| terminal ileum | ENPEP | 0.9653 | 8.29E-110 | 3355 | Q07075 | Glutamyl aminopeptidase | metalloprotease (PC00153) |
| terminal ileum | MEP1B | 0.9653 | 8.35E-110 | 7020 | Q16820 | Meprin A subunit beta | metalloprotease (PC00153) |
| terminal ileum | SLC15A1 | 0.9621 | 2.19E-106 | 10920 | P46059 | Solute carrier family 15 member 1 | transporter (PC00227) |
| terminal ileum | MEP1A | 0.9619 | 4.4E-106 | 7015 | Q16819 | Meprin A subunit alpha | metalloprotease (PC00153) |
| terminal ileum | SLC3A1 | 0.9608 | 5.63E-105 | 11025 | Q07837 | Neutral and basic amino acid transport protein rBAT | amylase (PC00048) |
| terminal ileum | APOB | 0.9587 | 6.45E-103 | 603 | P04114 | Apolipoprotein B-100 | |
| terminal ileum | SLC6A19 | 0.9581 | 2.33E-102 | 27960 | Q695T7 | Sodium-dependent neutral amino acid transporter B(0)AT1 | primary active transporter (PC00068) |
| terminal ileum | ANPEP | 0.9562 | 1.16E-100 | 500 | P15144 | Aminopeptidase N | metalloprotease (PC00153) |
| terminal ileum | MTTP | 0.9559 | 2.45E-100 | 7467 | P55157 | Microsomal triglyceride transfer protein large subunit | transporter (PC00227) |
| terminal ileum | TUBAL3 | 0.9554 | 6.24E-100 | 23534 | A6NHL2 | Tubulin alpha chain-like 3 | tubulin (PC00228) |
| testis | PLP1 | 0.9092 | 1.07E-138 | 9086 | P60201 | Myelin proteolipid protein | myelin protein (PC00161) |
| colon-transverse | MEP1A | 0.9056 | 1.52E-152 | 7015 | Q16819 | Meprin A subunit alpha | metalloprotease (PC00153) |
| kidney | TINAG | 0.9012 | 7.07E-32 | 14599 | Q9UJW2 | Tubulointerstitial nephritis antigen | cysteine protease (PC00081) |
| colon-transverse | GDA | 0.8964 | 8.19E-145 | 4212 | Q9Y2T3 | Guanine deaminase | deaminase (PC00088) |
| colon-transverse | MGAM2 | 0.8963 | 9E-145 | 28101 | Q2M2H8 | Probable maltase-glucoamylase 2 | glucosidase (PC00108) |
| colon-transverse | TMEM236 | 0.894 | 6.66E-143 | 23473 | Q5W0B7 | Transmembrane protein 236 | |
| colon-transverse | GDPD2 | 0.8935 | 1.58E-142 | 25974 | Q9HCC8 | Glycerophosphoinositol inositolphosphodiesterase GDPD2 | |
| colon-transverse | PLS1 | 0.8932 | 2.81E-142 | 9090 | Q14651 | Plastin-1 | non-motor actin binding protein (PC00165) |
| colon-transverse | HHLA2 | 0.893 | 3.59E-142 | 4905 | Q9UM44 | HERV-H LTR-associating protein 2 | immunoglobulin receptor superfamily (PC00124) |
| colon-transverse | SLC3A1 | 0.8928 | 5.27E-142 | 11025 | Q07837 | Neutral and basic amino acid transport protein rBAT | amylase (PC00048) |
| colon-transverse | COL17A1 | 0.8914 | 6.12E-141 | 2194 | Q9UMD9 | Collagen alpha-1(XVII) chain | extracellular matrix structural protein (PC00103) |
| testis | NDFIP1 | 0.8911 | 2.91E-125 | 17592 | Q9BT67 | NEDD4 family-interacting protein 1 | |
| testis | SPARC | 0.8908 | 4.67E-125 | 11219 | P09486 | SPARC | extracellular matrix glycoprotein (PC00100) |
| colon-transverse | TINAG | 0.8905 | 2.94E-140 | 14599 | Q9UJW2 | Tubulointerstitial nephritis antigen | cysteine protease (PC00081) |
| testis | SCP2 | 0.8886 | 1.34E-123 | 10606 | P22307 | Non-specific lipid-transfer protein | transfer/carrier protein (PC00219) |
| testis | SMARCA1 | 0.8852 | 2.44E-121 | 11097 | P28370 | Probable global transcription activator SNF2L1 | DNA helicase (PC00011) |
| testis | ATP2B1 | 0.8829 | 6.45E-120 | 814 | P20020 | Plasma membrane calcium-transporting ATPase 1 | primary active transporter (PC00068) |
| testis | VSIG1 | 0.8815 | 4.6E-119 | 28675 | Q86XK7 | V-set and immunoglobulin domain-containing protein 1 | |
| testis | HTATSF1 | 0.8809 | 1.09E-118 | 5276 | O43719 | HIV Tat-specific factor 1 | RNA splicing factor (PC00148) |
| testis | ACO1 | 0.8808 | 1.26E-118 | 117 | P21399 | Cytoplasmic aconitate hydratase | RNA binding protein (PC00031) |
| testis | ENPP5 | 0.8802 | 3.01E-118 | 13717 | Q9UJA9 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 | nucleotide phosphatase (PC00173) |
| kidney | METTL7B | 0.8705 | 2.78E-27 | 28276 | Q6UX53 | Methyltransferase-like protein 7B | methyltransferase (PC00155) |
| kidney | ANPEP | 0.8683 | 5.3E-27 | 500 | P15144 | Aminopeptidase N | metalloprotease (PC00153) |
| kidney | LRP2 | 0.8671 | 7.59E-27 | 6694 | P98164 | Low-density lipoprotein receptor-related protein 2 | |
| kidney | SLC13A1 | 0.8667 | 8.5E-27 | 10916 | Q9BZW2 | Solute carrier family 13 member 1 | secondary carrier transporter (PC00258) |
| kidney | UGT3A1 | 0.8608 | 4.52E-26 | 26625 | Q6NUS8 | UDP-glucuronosyltransferase 3A1 | |
| kidney | SLC27A2 | 0.8535 | 3.26E-25 | 10996 | O14975 | Very long-chain acyl-CoA synthetase | secondary carrier transporter (PC00258) |
| kidney | TMEM27 | 0.8526 | 4.1E-25 | 29437 | Q9HBJ8 | Collectrin | |
| kidney | CLRN3 | 0.8443 | 3.36E-24 | 20795 | Q8NCR9 | Clarin-3 | |
| kidney | ACP5 | 0.8367 | 2.05E-23 | 124 | P13686 | Tartrate-resistant acid phosphatase type 5 | |
| lung | PARM1 | 0.6275 | 1.32E-64 | 24536 | Q6UWI2 | Prostate androgen-regulated mucin-like protein 1 | |
| lung | CNR1 | 0.6055 | 4.21E-59 | 2159 | P21554 | Cannabinoid receptor 1 | G-protein coupled receptor (PC00021) |
| lung | NUDT16 | 0.5918 | 6.52E-56 | 26442 | Q96DE0 | U8 snoRNA-decapping enzyme | |
| lung | DUOX1 | 0.5817 | 1.23E-53 | 3062 | Q9NRD9 | Dual oxidase 1 | oxidase (PC00175) |
| lung | DUOXA1 | 0.5739 | 6.2E-52 | 26507 | Q1HG43 | Dual oxidase maturation factor 1 | |
| lung | FMN1 | 0.571 | 2.53E-51 | 3768 | Q68DA7 | Formin-1 | |
| lung | TMEM164 | 0.5692 | 6.05E-51 | 26217 | Q5U3C3 | Transmembrane protein 164 | |
| lung | HSD17B4 | 0.5673 | 1.54E-50 | 5213 | P51659 | Peroxisomal multifunctional enzyme type 2 | |
| lung | MGST1 | 0.5631 | 1.16E-49 | 7061 | P10620 | Microsomal glutathione S-transferase 1 | |
| lung | SHMT1 | 0.5594 | 6.77E-49 | 10850 | P34896 | Serine hydroxymethyltransferase, cytosolic | methyltransferase (PC00155) |