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. 2014 Oct 23;22(1):29–37. doi: 10.3727/096504014X14078436004987

Figure 3.

Figure 3

Knockdown of FOXM1 in NSCLC reversed the phenotype of TGF-β1-induced EMT. (A) H1650 and H1299 cells were incubated with TGF-β1 (5 ng/ml) for 72 h and then transfected with siRNA FOXM1 for 48 h. (A) Morphological changes were examined. (B) Western blot analysis of epithelial marker E-cadherin and mesenchymal marker vimentin. The effect of siRNA targeting FOXM1 on ERK and p-ERK was also detected. (C) The migration capacity of H1650 and H1299 cells treated with TGF-β1 and siRNA FOXM1 was determined by wound-healing assays (*p < 0.01).