TABLE 2.

Drugs Causing Moderate to Severe ST Symtoms⁴

Drug Classes	Drug Combinations
MAOIs	MAOIs + SSRIs or SNRIs or TCAs or opiates Imipramine + tranylcypromine Phenelzine + meperidine Methylene blue + clomipramine or paroxetine
SSRIs	SSRIs + MAOIs or TCAs or SNRIs or opiates or tryptans Fluoxetine + carbamazepine or phentermine or fentanyl
SNRIs	SNRIs + TCAs or MAOIs or opiates or triptans Fluoxetine + mirtazapine or phentermine or fentanyl
Other antidepressants	Mirtazapine + SSRIs Trazodone + amitriptyline + lithium
Opiates	Opiates + MAOIs or SSRIs or SNRIs or triptans
Cold remedies	Dextromethorphan + SSRIs or TCAs or atypical antipsychotics
Atypical antipsychotics	Olanzapine + citalopram and lithium Risperidone + paroxetine or fluoxetine
Antibiotics/antifungals	Linezolid + SSRIs or tapentadol Fluconazole + citalopram Ciprofloxacin + methadone + venlafaxine

Abbreviations: MAOIs, monoamine oxidase inhibitors; SNRIs, selective norepinephrine reuptake inhibitors; SSRIs, selective serotonin reuptake inhibitors; ST, serotonin toxicity; TCAs, tricyclic antidepressants.