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. 2020 Oct 16;16(10):e1008986. doi: 10.1371/journal.ppat.1008986

Fig 8. Percentages of Altered Core and IFNβ-specific ISGs that correlated with clinically relevant parameters during chronic mucosal HIV-1 infection.

Fig 8

Correlations between the expression of individual core-ISGs (Fig 6A) and IFNβ-specific ISGs (Fig 7A) in gut biopsies from the clinical cohort were determined against (A) gut IFNβ transcripts, (B) plasma LPS levels, (C) gut CD4+ T cell percentages, (D) Blood CD4 T cell counts and (E) Plasma IL6 levels using linear regression models, controlling for age and gender. The clinical cohort included PWH (n = 19) and matched HIV uninfected controls (n = 13). Correlations with FDR ≤ 5% were considered significant; the proportion of those core and beta ISGs are plotted as pie charts, with red, blue and gray depicting positive, negative and no significant correlations, respectively. The top genes in the relevant categories with ≥50% representation are highlighted; a full list is available in S12 Table.