Table 1.
Clinical baseline characteristics
Total group (n = 20) | |
---|---|
Age, years | 39±12 |
Gender, male | 11 (55) |
Family history of SCD in first-degree relatives | 8 (40) |
History of atrial flutter at age <35 years | 1 (5) |
Symptoms | |
Palpitations | 11 (55) |
Syncope | 9 (45) |
Near syncope | 4 (20) |
Systemic systolic ventricular function | |
Normal left ventricular ejection fraction (≥55%) | 20 (100) |
Genetic variance | |
No (likely) pathogenic SCN5A variant | 14 (70) |
No genetic testing | 4 (20) |
Pathogenic SCN5A variant | 2 (10) |
Clinical presentation | |
Ajmaline induced Brugada ECG | 14 (70) |
Fever induced Brugada ECG | 4 (20) |
Spontaneous Brugada ECG | 2 (10) |
Electrocardiography | |
Sinus rhythm | 20 (100) |
PR interval, ms | 169±28 |
QRS duration, ms | 103±18 |
QTc duration, ms | 391±22 |
Fragmented QRS | 4 (20) |
EP study | 7 (35) |
No inducible sustained VA | 7 (35) |
VERP <200 ms | 2 (10) |
Holter monitoring | 16 (80) |
No PVCs | 10 (50) |
≤1% PVCs | 6 (30) |
Supraventricular tachycardia | 0 |
Ventricular tachycardia | 0 |
SA-ECG | 16 (80) |
Late potentials | 10 (50) |
Data are presented as n (%) or mean ± standard deviation. ECG, electrocardiogram; EP, electrophysiological; PVC, premature ventricular arrhythmia; SCD, sudden cardiac death; VA, ventricular arrhythmia; VERP, ventricular effective refractory period.