Table 2. WMH assessment between children and adults.
| Children (n = 27) | Adults (n = 74) | p value | |
|---|---|---|---|
| Prevalence of WMH | |||
| Participants with WMH | 16/27 (59) | 74/74 (100) | < 0.001a |
| Quantitative and volumetric analyses | |||
| Absolute number of WMH | 5.0 (2.0–12.5) | 18 (9.3–37.5) | < 0.001b |
| Intracranial volume# | 1.52 (1.27–1.58) | 1.69 (1.59–1.80) | |
| Total WMH volume * | 109 (61.7–652) | 1182 (425–2617) | < 0.001b# |
| Location of WMH | |||
| Participants with deep WMH | 16/16 (100) | 71/74 (96) | 0.999a |
| Participants with periventricular WMH | 9/16 (56) | 74/74 (100) | < 0.001a |
| Absolute number deep WMH | 3.0 (2.0–11.3) | 11 (3.0–27.8) | 0.078b |
| Absolute number periventricular WMH | 1.0 (0.0–2.3) | 7.0 (6.0–10.8) | < 0.001b |
Abbreviations: HIV = human immunodeficiency virus
WMH = white matter hyperintensities
Values noted in amount and percentage n(%) or median and inter-quartile range (IQR)
Statistical tests
a = Fisher's exact test
b = Mann-Whitney U test
# unit = *106 μL
* unit = mm3
# adjusted p value (WMH to ICV ratio)